Parkinson's Disease: Low-Dose Haloperidol Increases Dopamine Receptor Sensitivity and Clinical Response
Identifieur interne : 000981 ( Main/Exploration ); précédent : 000980; suivant : 000982Parkinson's Disease: Low-Dose Haloperidol Increases Dopamine Receptor Sensitivity and Clinical Response
Auteurs : Craig J. Hudson [Canada] ; Philip Seeman [Canada] ; Mary V. Seeman [Canada]Source :
- Parkinson's Disease [ 2090-8083 ] ; 2014.
Abstract
Url:
DOI: 10.1155/2014/684973
PubMed: 25506040
PubMed Central: 4258318
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkinson's Disease: Low-Dose Haloperidol Increases Dopamine Receptor Sensitivity and Clinical Response</title><author><name sortKey="Hudson, Craig J" sort="Hudson, Craig J" uniqKey="Hudson C" first="Craig J." last="Hudson">Craig J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Psychiatry, Alexandra Marine and General Hospital, 120 Napier Street, Goderich, ON, Canada N7A 1W5</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychiatry, Alexandra Marine and General Hospital, 120 Napier Street, Goderich, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name><affiliation wicri:level="1"><nlm:aff id="I2">Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON, Canada M5P 3L6</nlm:aff><country>Canada</country><wicri:regionArea>Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seeman, Mary V" sort="Seeman, Mary V" uniqKey="Seeman M" first="Mary V." last="Seeman">Mary V. Seeman</name><affiliation wicri:level="1"><nlm:aff id="I2">Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON, Canada M5P 3L6</nlm:aff><country>Canada</country><wicri:regionArea>Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25506040</idno><idno type="pmc">4258318</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258318</idno><idno type="RBID">PMC:4258318</idno><idno type="doi">10.1155/2014/684973</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000388</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000388</idno><idno type="wicri:Area/Pmc/Curation">000388</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000388</idno><idno type="wicri:Area/Pmc/Checkpoint">000431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000431</idno><idno type="wicri:Area/Ncbi/Merge">001A02</idno><idno type="wicri:Area/Ncbi/Curation">001A02</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A02</idno><idno type="wicri:doubleKey">2090-8083:2014:Hudson C:parkinson:s:disease</idno><idno type="wicri:Area/Main/Merge">000983</idno><idno type="wicri:Area/Main/Curation">000981</idno><idno type="wicri:Area/Main/Exploration">000981</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkinson's Disease: Low-Dose Haloperidol Increases Dopamine Receptor Sensitivity and Clinical Response</title><author><name sortKey="Hudson, Craig J" sort="Hudson, Craig J" uniqKey="Hudson C" first="Craig J." last="Hudson">Craig J. Hudson</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Psychiatry, Alexandra Marine and General Hospital, 120 Napier Street, Goderich, ON, Canada N7A 1W5</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychiatry, Alexandra Marine and General Hospital, 120 Napier Street, Goderich, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name><affiliation wicri:level="1"><nlm:aff id="I2">Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON, Canada M5P 3L6</nlm:aff><country>Canada</country><wicri:regionArea>Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seeman, Mary V" sort="Seeman, Mary V" uniqKey="Seeman M" first="Mary V." last="Seeman">Mary V. Seeman</name><affiliation wicri:level="1"><nlm:aff id="I2">Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON, Canada M5P 3L6</nlm:aff><country>Canada</country><wicri:regionArea>Clera Inc., 260 Heath Street West, Unit 605, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinson's Disease</title><idno type="ISSN">2090-8083</idno><idno type="eISSN">2042-0080</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. It is known that ultra-low doses of haloperidol can cause dopamine supersensitivity of dopamine D2 receptors and related behaviour in animals. <italic>Objective</italic>. The objective was to determine whether a daily ultra-low dose of 40 micrograms of haloperidol could enhance the clinical action of levodopa in Parkinson's disease patients. <italic>Method</italic>. While continuing their daily treatment with levodopa, 16 patients with Parkinson's disease were followed weekly for six weeks. They received an add-on daily dose of 40 micrograms of haloperidol for the first two weeks only. The SPES/SCOPA scale (short scale for assessment of motor impairments and disabilities in Parkinson's disease) was administered before treatment and weekly throughout the trial. <italic>Results</italic>. The results showed a mean decrease in SPES/SCOPA scores after one week of the add-on treatment. <italic>Conclusion</italic>. SCOPA scores decreased after the addition of low-dose haloperidol to the standard daily levodopa dose. This finding is consistent with an increase in sensitivity of dopamine D2 receptors induced by haloperidol. Such treatment for Parkinson's disease may possibly permit the levodopa dose to be reduced and, thus, delay the onset of levodopa side effects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schapira, A H" uniqKey="Schapira A">A. H. Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seeman, P" uniqKey="Seeman P">P. Seeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seeman, P" uniqKey="Seeman P">P. Seeman</name></author><author><name sortKey="Weinshenker, D" uniqKey="Weinshenker D">D. Weinshenker</name></author><author><name sortKey="Quirion, R" uniqKey="Quirion R">R. Quirion</name></author><author><name sortKey="Srivastava, L K" uniqKey="Srivastava L">L. K. Srivastava</name></author><author><name sortKey="Bhardwaj, S K" uniqKey="Bhardwaj S">S. K. Bhardwaj</name></author><author><name sortKey="Grandy, D K" uniqKey="Grandy D">D. K. Grandy</name></author><author><name sortKey="Premont, R T" uniqKey="Premont R">R. T. Premont</name></author><author><name sortKey="Sotnikova, T D" uniqKey="Sotnikova T">T. D. Sotnikova</name></author><author><name sortKey="Boksa, P" uniqKey="Boksa P">P. Boksa</name></author><author><name sortKey="El Ghundi, M" uniqKey="El Ghundi M">M. El-Ghundi</name></author><author><name sortKey="O Dowd, B F" uniqKey="O Dowd B">B. F. O'Dowd</name></author><author><name sortKey="George, S R" uniqKey="George S">S. R. George</name></author><author><name sortKey="Perreault, M L" uniqKey="Perreault M">M. L. Perreault</name></author><author><name sortKey="M Nnisto, P T" uniqKey="M Nnisto P">P. T. Männistö</name></author><author><name sortKey="Robinson, S" uniqKey="Robinson S">S. Robinson</name></author><author><name sortKey="Palmiter, R D" uniqKey="Palmiter R">R. D. Palmiter</name></author><author><name sortKey="Tallerico, T" uniqKey="Tallerico T">T. Tallerico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alttoa, A" uniqKey="Alttoa A">A. Alttoa</name></author><author><name sortKey="Seeman, P" uniqKey="Seeman P">P. Seeman</name></author><author><name sortKey="Koiv, K" uniqKey="Koiv K">K. Koiv</name></author><author><name sortKey="Eller, M" uniqKey="Eller M">M. Eller</name></author><author><name sortKey="Harro, J" uniqKey="Harro J">J. Harro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seeman, P" uniqKey="Seeman P">P. Seeman</name></author><author><name sortKey="Schwarz, J" uniqKey="Schwarz J">J. Schwarz</name></author><author><name sortKey="Chen, J F" uniqKey="Chen J">J.-F. Chen</name></author><author><name sortKey="Szechtman, H" uniqKey="Szechtman H">H. Szechtman</name></author><author><name sortKey="Perreault, M" uniqKey="Perreault M">M. Perreault</name></author><author><name sortKey="Mcknight, G S" uniqKey="Mcknight G">G. S. McKnight</name></author><author><name sortKey="Roder, J C" uniqKey="Roder J">J. C. Roder</name></author><author><name sortKey="Quirion, R" uniqKey="Quirion R">R. Quirion</name></author><author><name sortKey="Boksa, P" uniqKey="Boksa P">P. Boksa</name></author><author><name sortKey="Srivastava, L K" uniqKey="Srivastava L">L. K. Srivastava</name></author><author><name sortKey="Yanai, K" uniqKey="Yanai K">K. Yanai</name></author><author><name sortKey="Weinshenker, D" uniqKey="Weinshenker D">D. Weinshenker</name></author><author><name sortKey="Sumiyoshi, T" uniqKey="Sumiyoshi T">T. Sumiyoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dias, F R C" uniqKey="Dias F">F. R. C. Dias</name></author><author><name sortKey="De Matos, L W" uniqKey="De Matos L">L. W. de Matos</name></author><author><name sortKey="De Fatima Dos Santos Sampaio, M" uniqKey="De Fatima Dos Santos Sampaio M">M. de Fátima dos Santos Sampaio</name></author><author><name sortKey="Carey, R J" uniqKey="Carey R">R. J. Carey</name></author><author><name sortKey="Carrera, M P" uniqKey="Carrera M">M. P. Carrera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seeman, P" uniqKey="Seeman P">P. Seeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapur, S" uniqKey="Kapur S">S. Kapur</name></author><author><name sortKey="Vanderspek, S C" uniqKey="Vanderspek S">S. C. VanderSpek</name></author><author><name sortKey="Brownlee, B A" uniqKey="Brownlee B">B. A. Brownlee</name></author><author><name sortKey="Nobrega, J N" uniqKey="Nobrega J">J. N. Nobrega</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marinus, J" uniqKey="Marinus J">J. Marinus</name></author><author><name sortKey="Visser, M" uniqKey="Visser M">M. Visser</name></author><author><name sortKey="Stiggelbout, A M" uniqKey="Stiggelbout A">A. M. Stiggelbout</name></author><author><name sortKey="Rabey, J M" uniqKey="Rabey J">J. M. Rabey</name></author><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P. Martínez-Martín</name></author><author><name sortKey="Bonuccelli, U" uniqKey="Bonuccelli U">U. Bonuccelli</name></author><author><name sortKey="Kraus, P H" uniqKey="Kraus P">P. H. Kraus</name></author><author><name sortKey="Van Hilten, J J" uniqKey="Van Hilten J">J. J. Van Hilten</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Hudson, Craig J" sort="Hudson, Craig J" uniqKey="Hudson C" first="Craig J." last="Hudson">Craig J. Hudson</name></noRegion><name sortKey="Seeman, Mary V" sort="Seeman, Mary V" uniqKey="Seeman M" first="Mary V." last="Seeman">Mary V. Seeman</name><name sortKey="Seeman, Philip" sort="Seeman, Philip" uniqKey="Seeman P" first="Philip" last="Seeman">Philip Seeman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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